Title: Electrospun Schizophyllan/polyvinyl alcohol blend nanofibrous scaffold as potential wound healing
Journal: International Journal of Biological Macromolecules
Author: 1. Jamal Rashidiani, Hamid Kooshki, 1,2. Mohammad Reza Safaee-Ardakani, 2. Ashrafalsadat Hatamian-Zarmi, Seyedeh Mahdieh Sadat, BahmanEbrahimi-Hosseinzadeh, 3. Zahra Beagom Mokhtari-Hosseini,
Year: 2019
Address: 1. Nanobiotechnology Research Center, Baqiyatallah University of Medical Science, Tehran, Iran 2. Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran 3. Chemical Engineering Group, Faculty of Petroleum and Petrochemical Engineering, Hakim Sabzevari University, Sabzevar, Iran
Abstract: In this study, aqueous Schizophyllan (SPG) (1.5 w/v%) was mixed with aqueous polyvinyl alcohol (PVA) (10 w/v%) at various volume ratios and electrospun to prepare nanofibers. The fiber diameter was decreased by increasing the SPG content. A reliable linear relationship (p < 0.01) was established between the solution properties and fiber diameter. Contiguous, bead-free, and smooth fibers were obtained when the SPG/PVA ratios were 20:80, 30:70, and 40:60. FT-IR spectra, SEM images, tensile testing, swelling ratios, and water contact angle were utilized to characterize this glutaraldehyde (Glu) vapor cross-linked nanofibers in order to analyze the morphology, functional groups, mechanical attributes, hydrophilicity, and humidity of the nanofibers for skin tissue regeneration. Furthermore, the cell culture that was studied by the use of fibroblast (L929) cells showed that these SPG-based nanofibrous scaffolds could generate the improved cell adhesion. In conclusion, it was observed that SPG/PVA nanofiber mat in a volume ratio of 20:80 after 3 day was a suitable material for improving the wound healing, as it could increase cell proliferation and migration that possessed fiber diameter. The characteristics of this nanofiber were 267 nm, contact angle of 47.75°, good swelling behavior (289%), the ultimate strength of 6.513 Mpa, Young modulus of 2.665 Mpa, and cell viability of 150%.
Keywords: Schizophyllan, Polyvinyl alcohol, Scaffold, Electrospinning, Wound healing
Application: Wound Dressing, Scaffold
Product Model 1: Electroris
Product Model 2:
URL: #https://www.sciencedirect.com/science/article/pii/S0141813018352851#